{"id":531,"date":"2025-03-10T15:02:13","date_gmt":"2025-03-10T06:02:13","guid":{"rendered":"https:\/\/www.hirokoku-u.ac.jp\/medical_care\/news\/?p=531"},"modified":"2025-03-10T15:02:13","modified_gmt":"2025-03-10T06:02:13","slug":"%e4%bf%9d%e5%81%a5%e5%8c%bb%e7%99%82%e5%ad%a6%e9%83%a8-%e5%8c%bb%e7%99%82%e6%8a%80%e8%a1%93%e5%ad%a6%e7%a7%91-%e4%b8%ad%e5%b1%b1%e5%87%86%e6%95%99%e6%8e%88%e3%82%89%e3%81%ae%e7%a0%94%e7%a9%b6%e8%ab%96","status":"publish","type":"post","link":"https:\/\/www.hirokoku-u.ac.jp\/medical_care\/news\/531\/","title":{"rendered":"\u4fdd\u5065\u533b\u7642\u5b66\u90e8 \u533b\u7642\u6280\u8853\u5b66\u79d1 \u4e2d\u5c71\u51c6\u6559\u6388\u3089\u306e\u7814\u7a76\u8ad6\u6587\u304c\u300cScientific Reports\u300d\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002"},"content":{"rendered":"<p>\uff1c\u6982\u8981\uff1e<\/p>\n<p>&nbsp;<\/p>\n<p>\u4e73\u764c\u306e\u7f79\u60a3\u7387\u306f\u5973\u6027\u306e\u764c\u306e\u4e2d\u3067\u6700\u3082\u9ad8\u304f\u3001\u73fe\u5728\u3067\u3082\u5897\u52a0\u306e\u4e00\u9014\u3092\u305f\u3069\u3063\u3066\u3044\u308b\u305f\u3081\u6df1\u523b\u306a\u793e\u4f1a\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u5e83\u5cf6\u56fd\u969b\u5927\u5b66 \u4fdd\u5065\u533b\u7642\u5b66\u90e8 \u533b\u7642\u6280\u8853\u5b66\u79d1 \u4e2d\u5c71\u51c6\u6559\u6388\u3089\u306f\u3001\u8ef8\u7d22\u8a98\u5c0e\u56e0\u5b50\u3068\u305d\u306e\u53d7\u5bb9\u4f53\u306e\u6a5f\u80fd\u306b\u7740\u76ee\u3057\u305f\u764c\u6cbb\u7642\u85ac\u306e\u958b\u767a\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u8ef8\u7d22\u8a98\u5c0e\u56e0\u5b50\u30bb\u30de\u30d5\u30a9\u30ea\u30f33F (SEMA3F)\u3068\u305d\u306e\u53d7\u5bb9\u4f53\u30cb\u30e5\u30fc\u30ed\u30d4\u30ea\u30f3-2 (NRP2)\u306b\u7740\u76ee\u3057\u3066\u4e73\u764c\u3092\u5bfe\u8c61\u3068\u3057\u305f\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u30de\u30a6\u30b9\u7531\u6765\u4e73\u764c\u7d30\u80de\u682a4T1\u7d30\u80de\u306b\u30d2\u30c8SEMA3F\u3092\u907a\u4f1d\u5b50\u5c0e\u5165\u3057\u3066\u5b89\u5b9a\u767a\u73fe\u682a\u3092\u4f5c\u6210\u3057\u3001Balb\/c\u30de\u30a6\u30b9\u4e73\u817a\u306b\u540c\u7a2e\u79fb\u690d\u3057\u3066\u816b\u760d\u3078\u306e\u5f71\u97ff\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001SEMA3F-4T1\u7d30\u80de\u79fb\u690d\u30de\u30a6\u30b9\u3067\u306f\u816b\u760d\u5897\u6b96\u3068\u816b\u760d\u8840\u7ba1\u65b0\u751f\u304c\u4f4e\u4e0b\u3057\u3001\u3055\u3089\u306b\u809d\u81d3\u304a\u3088\u3073\u80ba\u3078\u306e\u9060\u9694\u8ee2\u79fb\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001SEMA3F\u306fNRP2\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066\u5897\u6b96\u306b\u91cd\u8981\u306aAkt-mTOR\u30b7\u30b0\u30ca\u30eb\u304a\u3088\u3073\u8ee2\u79fb\u306b\u91cd\u8981\u306aTGF\u03b2\u30b7\u30b0\u30ca\u30eb\u3092\u6291\u5236\u3057\u3066\u4e0a\u76ae\u9593\u8449\u8ee2\u63db\uff08EMT\uff09\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306fSEMA3F\u3092\u6d3b\u7528\u3057\u305f\u6297\u816b\u760d\u85ac\u958b\u767a\u306b\u5411\u3051\u305f\u3001\u3055\u3089\u306a\u308b\u57fa\u790e\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-532\" src=\"https:\/\/www.hirokoku-u.ac.jp\/medical_care\/news\/wp-content\/uploads\/sites\/3\/2025\/03\/img.jpg\" alt=\"\" width=\"1000\" height=\"414\" srcset=\"https:\/\/www.hirokoku-u.ac.jp\/medical_care\/news\/wp-content\/uploads\/sites\/3\/2025\/03\/img.jpg 1000w, https:\/\/www.hirokoku-u.ac.jp\/medical_care\/news\/wp-content\/uploads\/sites\/3\/2025\/03\/img-300x124.jpg 300w, https:\/\/www.hirokoku-u.ac.jp\/medical_care\/news\/wp-content\/uploads\/sites\/3\/2025\/03\/img-768x318.jpg 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\uff1c\u8ad6\u6587\u60c5\u5831\uff1e<\/p>\n<p>&nbsp;<\/p>\n<p>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb<\/p>\n<p>Semaphorin 3F inhibits breast cancer metastasis by regulating the Akt-mTOR and TGF\u03b2 signaling pathways via neuropilin-2<\/p>\n<p>&nbsp;<\/p>\n<p>\u8a8c\u540d\u3001\u53f7\u3001\u756a\u53f7\uff08\u5e74\uff09<\/p>\n<p>Scientific Reports. 15(1):7394 (2025)<\/p>\n<p>&nbsp;<\/p>\n<p>\u8457\u8005<\/p>\n<p>Hironao Nakayama, Akari Murakami, Hisayo Nishida-Fukuda, Shinji Fukuda,<\/p>\n<p>Erina Matsugi, Masako Nakahara, Chiaki Kusumoto, Yoshiaki Kamei, Shigeki Higashiyama<\/p>\n<p>&nbsp;<\/p>\n<p>\u8ad6\u6587\u63b2\u8f09\u30da\u30fc\u30b8<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40033046\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/40033046\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uff1c\u6982\u8981\uff1e &nbsp; 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