Naoki Teno, Yusuke Iguchi, Yukiko Yamashita, Nobuhiro Mori, Mizuho Une,
Tomoko Nishimaki-Mogami, Keigo Gohda. Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists. Bioorg. Med. Chem. 25: 1787–1794 (2017)

Kyosuke Fujita, Yusuke Iguchi, Mizuho Une and Shiro Watanabe. Ursodeoxycholic acid suppresses lipogenesis in mouse liver: possible role of the decrease in β-muricholic acid, a farnesoid X receptor antagonist. Lipids 52: 335-344 (2017)

Lee R. Hagey, Shoujiro Ogawa, Narimi Kato, Rika Satoh(nee Okihara), Mizuho Une, Kuniko Mitamura, Shigeo Ikegawa, Masomitsu Maekawa, Alan F. Hofmann, and Takashi Iida.  A novel varanic acid epimer-(24R,25S)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-27-oic acid – is a major biliary bile acid in two varanid lizards and the Gila monster. Steroids 77: 1510-1521 (2012)

Lee R. Hagey, Shoujiro Ogawa, Narimi Kato, Rika Satoh(nee Okihara), Mizuho Une, Kuniko Mitamura, Shigeo Ikegawa, Masomitsu Maekawa, Alan F. Hofmann, and Takashi Iida. A novel varanic acid epimer-(24R,25S)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-27-oic acid – is a major biliary bile acid in two varanid lizards and the Gila monster. Steroids 77: 1510-1521 (2012)

Yusuke Iguchi, Tomoko Nishimaki-Mogami, Masafumi Yamaguchi, Fumiteru Teraoka, Tetsuo Kaneko and Mizuho Une Effects of chemical modification of ursodeoxycholic acid on TGR5 activation. Biol. Pharm..Bull 34: 1-7 (2011)

Lee R.Hagey, Takashi Iida, Hideyuki Tamagai, Shoujiro Ogawa, Mizuho Une, Kiyoshi Asahina, Kumiko Mushiake, Takaaki Goto, Nariyasu Mano, Junichi Goto, Matthew D.Krasowski, and Alan F. Hofmann. Major biliary bile acids of the Medaka (Oryzias latipes): 25R- and 25S-epimers of 3alpha,7 alpha,12 alpha -trihydroxy-5beta-cholestanoic acid. Zoological Science 27:565-573 (2010)

Yusuke Iguchi , Kenji Kihira, Tomoko Nishimaki-Mogami and Mizuho Une. Structure-activity relationship of bile alcohols as human farnesoid X receptor agonist Steroids 75: 95-100 (2010)
Yusuke Iguchi , Kenji Kihira, Tomoko Nishimaki-Mogami, Masahumi Yamaguchi and Mizuho Une. Bile alcohols function as the ligands of membrane-type bile acid-activated G-protein-coupled receptor. J.Lipid Res. 51:1432-1441 (2010)

H.Nittono, H.Takei, A.Unno, A.Kimura, T.Shimizu, T.Kurosawa, M.Tohma, and M.Une. Diagnostic determination system for high-risk screening for inborn errors of bile acid metabolism based on an analysis of urinary bile acids using gas chromatography-mass spectrometry: Results for 10 years in Japan. Pediatr. Int. 51:535-543 (2009)

H.Sato, A.Macchiarulo, C.Thomas, A.Gioiello, M.Une, A.F.Hofmann, R.Saladin, K.Schoonjans, R.Pellicciari, and J.Auwerx. Novel potent and selective bile acid derivatives as TGR5 agonists: Biological screening, structure-activity relationships and molecular modeling studies. J.Med.Chem. 51(6):1831-1841 (2008)

T. Nishimaki-Mogami, Y.Kawahara, N.Tamehiro, T.Yoshida, K.Inoue, Y.Ohno, T.Nagao, and M.Une. 5-Bile alcohols function as farnesoid X receptor antagonists. Biochem.Biophys.Res.Commun. 339:386-391 (2006)
T. Fujino, M. Une, T. Imanaka, K. Inoue, and T. Nishimaki-Mogami. Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation. J.Lipid Res. 45:132-138 (2004)

T. Nishimaki-Mogami, M.Une, T. Fujino, Y. Sato, N. Tamehiro, Y. Kawahara, K. Shudo, and K. Inoue. Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor. J. Lipid Res. 45:1538-1545(2004)