{"id":55,"date":"2017-03-06T10:12:33","date_gmt":"2017-03-06T01:12:33","guid":{"rendered":"https:\/\/www.hirokoku-u.ac.jp\/rehabilitation\/info\/stafflist\/?p=55"},"modified":"2022-09-13T12:03:13","modified_gmt":"2022-09-13T03:03:13","slug":"%e5%be%8c%e8%97%a4-%e5%8a%9b","status":"publish","type":"post","link":"https:\/\/www.hirokoku-u.ac.jp\/rehabilitation\/info\/stafflist\/?p=55","title":{"rendered":"\u5f8c\u85e4 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\/>\n\u305d\u3093\u306a\u81ea\u5206\u81ea\u8eab\u3067\u3059\u304c\u3001\u3044\u304b\u306b\u6642\u9593\u3092\u6709\u52b9\u306b\u4f7f\u3046\u304b\u3001\u3057\u305f\u3044\u4e8b\u3068\u3059\u3079\u304d\u4e8b\u3092\u660e\u78ba\u306b\u3057\u3059\u3079\u304d\u4e8b\u304b\u3089\u5b9f\u884c\u3059\u308b\u3001\u3068\u3044\u3046\uff12\u3064\u3092\u65e5\u3005\u306e\u751f\u6d3b\u306e\u30e1\u30a4\u30f3\u30c6\u30fc\u30de\u3068\u3057\u3066\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3>\u6559\u80b2\u65b9\u91dd<\/h3>\n<p>\u5927\u5b66\u3068\u3044\u3046\u5834\u6240\u306f\u52c9\u5f37\u3059\u308b\u3053\u3068\u3092\u81ea\u3089\u306e\u610f\u601d\u3067\u9078\u3093\u3067\u304d\u3066\u3044\u308b\u4eba\u305f\u3061\u304c\u96c6\u307e\u3063\u3066\u3044\u308b\u5834\u6240\u3001\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u533b\u7642\u7cfb\u306e\u5b66\u554f\u3092\u9078\u629e\u3059\u308b\u4eba\u305f\u3061\u306f\u3001\u4eba\u306e\u305f\u3081\u306b\u306a\u306b\u304b\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u305f\u3044\u3001\u3068\u3044\u3046\u610f\u601d\u3092\u6301\u3063\u3066\u3044\u308b\u3082\u306e\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u306b\u5927\u5b66\uff14\u5e74\u9593\u3067\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3053\u3068\u3092\u304d\u3063\u3061\u308a\u3068\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u5f53\u5b66\u79d1\u306e\u6388\u696d\u306f\u3068\u3066\u3082\u5927\u5909\u3067\u3059\u3002\u65e5\u3005\u3001\u81ea\u3089\u7e70\u308a\u8fd4\u3057\u52c9\u5f37\u3057\u306a\u3051\u308c\u3070\u5927\u5909\u306a\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<h3>\u7d4c\u6b74<\/h3>\n<h4>\u5b66\u6b74<\/h4>\n<table 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width=\"20%\">\u5e73\u62106<\/th>\n<td>\u30b7\u30e0\u30e9\u75c5\u9662<\/td>\n<\/tr>\n<tr>\n<th>\u5e73\u621018<\/th>\n<td>\u5e83\u5cf6\u56fd\u969b\u5927\u5b66\u533b\u7642\u4fdd\u5065\u533b\u7642\u5b66\u90e8\u7406\u5b66\u7642\u6cd5\u5b66\u79d1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>\u7406\u5b66\u7642\u6cd5\u6982\u8ad6<\/h3>\n<p>\uff11\u5e74\u751f\u306e\u524d\u671f\u306b\u3042\u308b\u6388\u696d\u3067\u3059\u3002\u81e8\u5e8a\u306b\u304a\u3051\u308b\u4ed5\u4e8b\u5185\u5bb9\u3084\u5206\u91ce\u306a\u3069\u3092\u4e2d\u5fc3\u306b\u8b1b\u7fa9\u3092\u884c\u3044\u307e\u3059\u3002\u305d\u306e\u4ed6\u3001\u5927\u5b66\u3067\u306e\u65e5\u5e38\u3067\u306e\u5fc3\u69cb\u3048\u3084\u52c9\u5f37\u65b9\u6cd5\u306a\u3069\u306b\u3064\u3044\u3066\u3082\u8a73\u7d30\u306b\u8a71\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\n<h3>\u751f\u6d3b\u6280\u8853\u5b66<\/h3>\n<p>\uff12\u5e74\u751f\u306e\u524d\u671f\u306b\u3042\u308b\u6388\u696d\u3067\u3059\u3002\u65e5\u5e38\u751f\u6d3b\u3092\u3069\u306e\u3088\u3046\u306b\u3068\u3089\u3048\u308b\u306e\u304b\u3001\u305d\u306e\u305f\u3081\u306e\u624b\u6bb5\u3084\u8003\u3048\u65b9\u3092\u52c9\u5f37\u3057\u307e\u3059\u3002\u89e3\u5256\u5b66\u3001\u751f\u7406\u5b66\u3001\u904b\u52d5\u5b66\u3092\u3057\u3063\u304b\u308a\u899a\u3048\u3066\u306a\u3044\u3068\u5927\u5909\u3067\u3059\u3002\uff11\u5e74\u751f\u306e\u5185\u5bb9\u3092\u3057\u3063\u304b\u308a\u53d6\u308a\u7d44\u3093\u3067\u304f\u3060\u3055\u3044\u3002<\/p>\n<h3>\u751f\u6d3b\u6280\u8853\u5b66\u5b9f\u7fd2<\/h3>\n<p>\uff12\u5e74\u751f\u306e\u5f8c\u671f\u306b\u3042\u308b\u6388\u696d\u3067\u3059\u3002\u524d\u671f\u306e\u5ea7\u5b66\u306e\u5185\u5bb9\u3092\u53d7\u3051\u3066\u3001\u57fa\u672c\u7684\u306a\u4ecb\u52a9\u624b\u6280\u306e\u7df4\u7fd2\u3084\u4eba\u306e\u52d5\u4f5c\u3092\u5206\u6790\u3059\u308b\u4e8b\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\n<h3>\u5185\u90e8\u969c\u5bb3\u5b66<\/h3>\n<p>\uff13\u5e74\u751f\u306e\u524d\u671f\u306b\u3042\u308b\u6388\u696d\u3067\u3059\u3002\u547c\u5438\u3001\u5faa\u74b0\u3001\u4ee3\u8b1d\u7cfb\u306e\u8a55\u4fa1\u3084\u4ecb\u5165\u306b\u3064\u3044\u3066\u5b66\u3073\u307e\u3059\u3002\u904b\u52d5\u751f\u7406\u5b66\u7684\u306a\u8981\u7d20\u304c\u591a\u304f\u542b\u307e\u308c\u307e\u3059\u3002\u89e3\u5256\u5b66\u3001\u751f\u7406\u5b66\u3001\u904b\u52d5\u5b66\u3001\u75be\u60a3\u5b66\u3092\u7cfb\u7d71\u7acb\u3066\u3066\u52c9\u5f37\u3057\u3066\u304a\u304f\u3053\u3068\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<h3>\u5185\u90e8\u969c\u5bb3\u5b66\u5b9f\u7fd2<\/h3>\n<p>\uff13\u5e74\u751f\u306e\u524d\u671f\u306b\u3042\u308b\u6388\u696d\u3067\u3059\u3002\u5ea7\u5b66\u3068\u540c\u6642\u9032\u884c\u3067\u6388\u696d\u304c\u3042\u308a\u307e\u3059\u3002\u5185\u79d1\u9818\u57df\u306e\u75be\u60a3\u306e\u8a55\u4fa1\u3001\u5b9f\u6280\u3092\u884c\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u81ea\u8eab\u306e\u8eab\u4f53\u3092\u4f7f\u3063\u3066\u904b\u52d5\u751f\u7406\u5b66\u7684\u306a\u30c7\u30fc\u30bf\u3092\u8a08\u6e2c\u3059\u308b\u3053\u3068\u3067\u3001\u904b\u52d5\u3068\u751f\u7406\u6a5f\u80fd\u306e\u5909\u5316\u306b\u3064\u3044\u3066\u8003\u5bdf\u3057\u307e\u3059\u3002<\/p>\n<h3>\u30c1\u30e5\u30fc\u30c8\u30ea\u30a2\u30eb<\/h3>\n<p>\u5b66\u751f\u3055\u3093\u306e\u751f\u6d3b\u3001\u6210\u7e3e\u3092\u628a\u63e1\u3057\u534a\u671f\u306b\u4e00\u5ea6\u3001\u5b9a\u671f\u7684\u306b\u9762\u8ac7\u3092\u884c\u3044\u307e\u3059\u3002\u3082\u3061\u308d\u3093\u3001\u6210\u7e3e\u304c\u82b3\u3057\u304f\u306a\u3044\u3001\u6388\u696d\u306e\u51fa\u5e2d\u7387\u304c\u60aa\u3044\u3001\u306a\u3069\u306e\u5b66\u751f\u3055\u3093\u306b\u5bfe\u3057\u3066\u306f\u305d\u306e\u90fd\u5ea6\u5bfe\u5fdc\u3057\u307e\u3059\u3002\u5148\u306b\u8ff0\u3079\u305f\u3088\u3046\u306b\u52c9\u5f37\u306e\u305f\u3081\u306b\u5927\u5b66\u9032\u5b66\u3092\u9078\u3073\u3001\u307e\u305f\u533b\u7642\u5f93\u4e8b\u8005\u306b\u306a\u308b\u3053\u3068\u3092\u5fd7\u3057\u3066\u3044\u308b\u304b\u3089\u306b\u306f\u6210\u7e3e\u306e\u307f\u306a\u3089\u305a\u65e5\u5e38\u306b\u304a\u3051\u308b\u614b\u5ea6\u306a\u3069\u306b\u3064\u3044\u3066\u306f\u3057\u3063\u304b\u308a\u3068\u8003\u3048\u3066\u3082\u3089\u3044\u307e\u3059\u3002<\/p>\n<h3>\u30bc\u30df<\/h3>\n<p>\u547c\u5438\u3001\u5faa\u74b0\u9818\u57df\u3092\u4e2d\u5fc3\u306b\u5352\u696d\u7814\u7a76\u306b\u53d6\u308a\u7d44\u307f\u307e\u3059\u3002\u904b\u52d5\u751f\u7406\u5b66\u7684\u3068\u89e3\u5256\u5b66\u304c\u3057\u3063\u304b\u308a\u3068\u7406\u89e3\u3067\u304d\u3066\u3044\u306a\u3044\u3068\u96e3\u3057\u3044\u5185\u5bb9\u3067\u3059\u3002\u53b3\u3057\u304f\u81e8\u307f\u307e\u3059\u306e\u3067\u3001\u305d\u308c\u306a\u308a\u306e\u610f\u601d\u3092\u6301\u3063\u3066\u9078\u629e\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u307e\u305f\u30bc\u30df\u5185\u3067\u306f\u52c9\u5f37\u6642\u9593\u3092\u6307\u5b9a\u3057\u3066\u65e9\u3044\u6bb5\u968e\u304b\u3089\u56fd\u5bb6\u8a66\u9a13\u52c9\u5f37\u306b\u3082\u53d6\u308a\u7d44\u3093\u3067\u3082\u3089\u3044\u307e\u3059\u3002<\/p>\n<h3>\u7814\u7a76\u5ba4\u7d39\u4ecb<\/h3>\n<p>\u672c\u7814\u7a76\u5ba4\u306b\u304a\u3044\u3066\u306f\u547c\u5438\u3001\u5faa\u74b0\u306b\u95a2\u3057\u3066\u306e\u7814\u7a76\u3092\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u3002\u7279\u306b\u904b\u52d5\u306b\u304a\u3051\u308b\u751f\u7406\u6a5f\u80fd\u306e\u5909\u5316\u306b\u3064\u3044\u3066\u6bd4\u8f03\u691c\u8a0e\u3059\u308b\u3053\u3068\u3092\u4e3b\u306b\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u3002\u904b\u52d5\u304c\u8eab\u4f53\u306b\u3069\u306e\u3088\u3046\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u3088\u308a\u52b9\u7387\u7684\u306a\u904b\u52d5\u5b9f\u65bd\u306e\u305f\u3081\u306e\u4e00\u52a9\u3068\u306a\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\n<h3>\u696d\u7e3e<\/h3>\n<ul class=\"ul_B\">\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21998134\" target=\"_blank\" rel=\"noopener noreferrer\">Geranylgeranylacetone, heat shock protein 90\/AMP-activated protein kinase\/endothelial nitric oxide synthase\/nitric oxide pathway, and endothelial function in humans.<\/a><br \/>\nFujimura N, Jitsuiki D, Maruhashi T, Mikami S, Iwamoto Y, Kajikawa M, Chayama K, Kihara Y, Noma K, <strong>Goto C<\/strong>, Higashi Y.<br \/>\nArterioscler Thromb Vasc Biol. 2012 Jan;32(1):153-60. Epub 2011 Oct 13.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21035804\" target=\"_blank\" rel=\"noopener noreferrer\">Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS\/t-MBS in comparison with vascular response to fasudil.<\/a><br \/>\nHata T, <strong>Goto C<\/strong>, Soga J, Hidaka T, Fujii Y, Idei N, Fujimura N, Maruhashi T, Mikami S, Kihara Y, Chayama K, Noma K, Liao JK, Higashi Y.<br \/>\nAtherosclerosis. 2011 Jan;214(1):117-21. Epub 2010 Oct 12.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20064642\" target=\"_blank\" rel=\"noopener noreferrer\">Pioglitazone improves endothelium-dependent vasodilation in hypertensive patients with impaired glucose tolerance in part through a decrease in oxidative stress.<\/a><br \/>\nHidaka T, Nakagawa K, <strong>Goto C<\/strong>, Soga J, Fujii Y, Hata T, Idei N, Fujimura N, Chayama K, Kihara Y, Higashi Y.<br \/>\nAtherosclerosis. 2010 Jun;210(2):521-4. Epub 2010 Jan 4.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19834330\" target=\"_blank\" rel=\"noopener noreferrer\">Sarpogrelate hydrochloride, a selective 5-hydroxytryptamine(2A) antagonist, augments autologous bone marrow mononuclear cell implantation-induced improvement in endothelium-dependent vasodilation in patients with critical limb ischemia.<\/a><br \/>\nHigashi Y, Miyazaki M, <strong>Goto C<\/strong>, Sanada H, Sueda T, Chayama K.<br \/>\nJ Cardiovasc Pharmacol. 2010 Jan;55(1):56-61.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19410250\" target=\"_blank\" rel=\"noopener noreferrer\">Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease.<\/a><br \/>\nHigashi Y, <strong>Goto C<\/strong>, Hidaka T, Soga J, Nakamura S, Fujii Y, Hata T, Idei N, Fujimura N, Chayama K, Kihara Y, Taguchi A.<br \/>\nAtherosclerosis. 2009 Oct;206(2):604-10. Epub 2009 Apr 5.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19237681\" target=\"_blank\" rel=\"noopener noreferrer\">Cigarette smoking abolishes ischemic preconditioning-induced augmentation of endothelium-dependent vasodilation.<\/a><br \/>\nNakamura S, Kimura M, <strong>Goto C<\/strong>, Noma K, Yoshizumi M, Chayama K, Kihara Y, Higashi Y.<br \/>\nHypertension. 2009 Apr;53(4):674-81. Epub 2009 Feb 23.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18957798\" target=\"_blank\" rel=\"noopener noreferrer\">Relationship between augmentation index and flow-mediated vasodilation in the brachial artery.<\/a><br \/>\nSoga J, Nakamura S, Nishioka K, Umemura T, Jitsuiki D, Hidaka T, Teragawa H, Takemoto H, <strong>Goto C<\/strong>, Yoshizumi M, Chayama K, Higashi Y.<br \/>\nHypertens Res. 2008 Jul;31(7):1293-8.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18787520\" target=\"_blank\" rel=\"noopener noreferrer\">Aging and hypertension are independent risk factors for reduced number of circulating endothelial progenitor cells.<\/a><br \/>\nUmemura T, Soga J, Hidaka T, Takemoto H, Nakamura S, Jitsuiki D, Nishioka K, <strong>Goto C<\/strong>, Teragawa H, Yoshizumi M, Chayama K, Higashi Y.<br \/>\nAm J Hypertens. 2008 Nov;21(11):1203-9. Epub 2008 Sep 11.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18039979\" target=\"_blank\" rel=\"noopener noreferrer\">Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients.<\/a><br \/>\nHigashi Y, <strong>Goto C<\/strong>, Jitsuiki D, Umemura T, Nishioka K, Hidaka T, Takemoto H, Nakamura S, Soga J, Chayama K, Yoshizumi M, Taguchi A.<br \/>\nHypertension. 2008 Feb;51(2):446-53. Epub 2007 Nov 26.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18037769\" target=\"_blank\" rel=\"noopener noreferrer\">Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans.<\/a><br \/>\nNishioka K, Hidaka T, Nakamura S, Umemura T, Jitsuiki D, Soga J, <strong>Goto C<\/strong>, Chayama K, Yoshizumi M, Higashi Y.<br \/>\nHypertens Res. 2007 Sep;30(9):775-80.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17679027\" target=\"_blank\" rel=\"noopener noreferrer\">Acute moderate-intensity exercise induces vasodilation through an increase in nitric oxide bioavailiability in humans.<\/a><br \/>\n<strong>Goto C<\/strong>, Nishioka K, Umemura T, Jitsuiki D, Sakagutchi A, Kawamura M, Chayama K, Yoshizumi M, Higashi Y.<br \/>\nAm J Hypertens. 2007 Aug;20(8):825-30.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17457001\" target=\"_blank\" rel=\"noopener noreferrer\">Measurement of flow-mediated vasodilation of the brachial artery: a comparison of measurements in the seated and supine positions.<\/a><br \/>\nSoga J, Nishioka K, Nakamura S, Umemura T, Jitsuiki D, Hidaka T, Teragawa H, Takemoto H, <strong>Goto C<\/strong>, Yoshizumi M, Chayama K, Higashi Y.<br \/>\nCirc J. 2007 May;71(5):736-40.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17438407\" target=\"_blank\" rel=\"noopener noreferrer\">Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease.<\/a><br \/>\nMiyazaki M, Higashi Y, <strong>Goto C<\/strong>, Chayama K, Yoshizumi M, Sanada H, Orihashi K, Sueda T.<br \/>\nJ Cardiovasc Pharmacol. 2007 Apr;49(4):221-7.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17291936\" target=\"_blank\" rel=\"noopener noreferrer\">Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness.<\/a><br \/>\nNoma K, <strong>Goto C<\/strong>, Nishioka K, Jitsuiki D, Umemura T, Ueda K, Kimura M, Nakagawa K, Oshima T, Chayama K, Yoshizumi M, Liao JK, Higashi Y.<br \/>\nJ Am Coll Cardiol. 2007 Feb 13;49(6):698-705. Epub 2007 Jan 26.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17228074\" target=\"_blank\" rel=\"noopener noreferrer\">Carvedilol improves endothelium-dependent vasodilation in patients with dilated cardiomyopathy.<\/a><br \/>\nNishioka K, Nakagawa K, Umemura T, Jitsuiki D, Ueda K, <strong>Goto C<\/strong>, Chayama K, Yoshizumi M, Higashi Y.<br \/>\nHeart. 2007 Feb;93(2):247-8. No abstract available.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17126666\" target=\"_blank\" rel=\"noopener noreferrer\">Effects of acute administration of caffeine on vascular function.<\/a><br \/>\nUmemura T, Ueda K, Nishioka K, Hidaka T, Takemoto H, Nakamura S, Jitsuiki D, Soga J, <strong>Goto C<\/strong>, Chayama K, Yoshizumi M, Higashi Y.<br \/>\nAm J Cardiol. 2006 Dec 1;98(11):1538-41. Epub 2006 Oct 16.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16210569\" target=\"_blank\" rel=\"noopener noreferrer\">Smoking, endothelial function, and Rho-kinase in humans.<\/a><br \/>\nNoma K, <strong>Goto C<\/strong>, Nishioka K, Hara K, Kimura M, Umemura T, Jitsuiki D, Nakagawa K, Oshima T, Chayama K, Yoshizumi M, Higashi Y.<br \/>\nArterioscler Thromb Vasc Biol. 2005 Dec;25(12):2630-5. Epub 2005 Oct 6.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16129443\" target=\"_blank\" rel=\"noopener noreferrer\">Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production.<\/a><br \/>\nHigashi Y, Sasaki S, Nakagawa K, Kimura M, Noma K, Hara K, Jitsuiki D, <strong>Goto C<\/strong>, Oshima T, Chayama K, Yoshizumi M.<br \/>\nAtherosclerosis. 2006 Jun;186(2):390-5. Epub 2005 Aug 29.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15772515\" target=\"_blank\" rel=\"noopener noreferrer\">The nicorandil-induced vasodilation in humans is inhibited by miconazole.<\/a><br \/>\nUeda K, <strong>Goto C<\/strong>, Jitsuiki D, Umemura T, Nishioka K, Kimura M, Noma K, Nakagawa K, Oshima T, Yoshizumi M, Chayama K, Higashi Y.<br \/>\nJ Cardiovasc Pharmacol. 2005 Apr;45(4):290-4.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15585216\" target=\"_blank\" rel=\"noopener noreferrer\">Vascular function in patients with lower extremity peripheral arterial disease: a comparison of functions in upper and lower extremities.<\/a><br \/>\nSanada H, Higashi Y, <strong>Goto C<\/strong>, Chayama K, Yoshizumi M, Sueda T.<br \/>\nAtherosclerosis. 2005 Jan;178(1):179-85.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15476630\" target=\"_blank\" rel=\"noopener noreferrer\">Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers.<\/a><br \/>\nJitsuiki D, Higashi Y, <strong>Goto C<\/strong>, Kimura M, Noma K, Hara K, Nakagawa K, Oshima T, Chayama K, Yoshizumi M.<br \/>\nAm J Cardiol. 2004 Oct 15;94(8):1070-3.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15007007\" target=\"_blank\" rel=\"noopener noreferrer\">Autologous bone-marrow mononuclear cell implantation improves endothelium-dependent vasodilation in patients with limb ischemia.<\/a><br \/>\nHigashi Y, Kimura M, Hara K, Noma K, Jitsuiki D, Nakagawa K, Oshima T, Chayama K, Sueda T, <strong>Goto C<\/strong>, Matsubara H, Murohara T, Yoshizumi M.<br \/>\nCirculation. 2004 Mar 16;109(10):1215-8. Epub 2004 Mar 8.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12875761\" target=\"_blank\" rel=\"noopener noreferrer\">Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress.<\/a><br \/>\nHigashi Y, Sasaki S, Nakagawa K, Kimura M, Noma K, Sasaki S, Hara K, Matsuura H, <strong>Goto C<\/strong>, Oshima T, Chayama K, Yoshizumi M.<br \/>\nJ Am Coll Cardiol. 2003 Jul 16;42(2):256-63.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12874192\" target=\"_blank\" rel=\"noopener noreferrer\">Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress.<\/a><br \/>\n<strong>Goto C<\/strong>, Higashi Y, Kimura M, Noma K, Hara K, Nakagawa K, Kawamura M, Chayama K, Yoshizumi M, Nara I.<br \/>\nCirculation. 2003 Aug 5;108(5):530-5. Epub 2003 Jul 21.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12682081\" target=\"_blank\" rel=\"noopener noreferrer\">Smoking activates rho-kinase in smooth muscle cells of forearm vasculature in humans.<\/a><br \/>\nNoma K, Higashi Y, Jitsuiki D, Hara K, Kimura M, Nakagawa K, <strong>Goto C<\/strong>, Oshima T, Yoshizumi M, Chayama K.<br \/>\nHypertension. 2003 May;41(5):1102-5. Epub 2003 Apr 7.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12695418\" target=\"_blank\" rel=\"noopener noreferrer\">PDE5 inhibitor sildenafil citrate augments endothelium-dependent vasodilation in smokers.<\/a><br \/>\nKimura M, Higashi Y, Hara K, Noma K, Sasaki S, Nakagawa K, <strong>Goto C<\/strong>, Oshima T, Yoshizumi M, Chayama K.<br \/>\nHypertension. 2003 May;41(5):1106-10. Epub 2003 Apr 14.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12475467\" target=\"_blank\" rel=\"noopener noreferrer\">Circadian variation of blood pressure and endothelial function in patients with essential hypertension:a comparison of dippers and non-dippers.<\/a><br \/>\nHigashi Y, Nakagawa K, Kimura M, Noma K, Hara K, Sasaki S, <strong>Goto C<\/strong>, Oshima T, Chayama K, Yoshizumi M.<br \/>\nJ Am Coll Cardiol. 2002 Dec 4;40(11):2039-43.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11973410\" target=\"_blank\" rel=\"noopener noreferrer\">Severity of hypertension affects improved resistance artery endothelial function by angiotensin-converting enzyme inhibition.<\/a><br \/>\nHigashi Y, Sasaki S, Nakagawa K, Kimura M, Sasaki S, Noma K, Hara K, Matsuura H, <strong>Goto C<\/strong>, Oshima T, Chayama K.<br \/>\nJ Cardiovasc Pharmacol. 2002 May;39(5):668-76.<\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11882600\" target=\"_blank\" rel=\"noopener noreferrer\">Excess norepinephrine impairs both endothelium-dependent and -independent vasodilation in patients with pheochromocytoma.<\/a><br \/>\nHigashi Y, Sasaki S, Nakagawa K, Kimura M, Sasaki S, Noma K, Matsuura H, Hara K, <strong>Goto C<\/strong>, Oshima T, Chayama K.<br \/>\nHypertension. 2002 Feb;39(2 Pt 2):513-8.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u81ea\u5df1\u7d39\u4ecb \u5927\u5b66\u306b\u6765\u308b\u3068\u82e5\u3044\u5b66\u751f\u3055\u3093\u306e\u52e2\u3044\u306b\u5727\u5012\u3055\u308c\u305d\u3046\u306b\u306a\u308b\u3053\u3068\u304c\u3057\u3070\u3057\u3070\u3042\u308b\u3088\u3046\u306a\u5e74\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u82e5\u3055\u3001\u3068\u3044\u3046\u591a\u304f\u306e\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u308b\u5b66\u751f\u3055\u3093\u304c\u6210\u9577\u3059\u308b\u59ff\u3092\u898b\u308b\u4e8b\u3092\u3068\u3066\u3082\u697d\u3057\u307f\u306b\u3057\u3066\u3044\u307e\u3059\u3002 \u305d\u3093\u306a\u81ea\u5206\u81ea\u8eab\u3067\u3059\u304c\u3001 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":56,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hirokoku-u.ac.jp\/rehabilitation\/info\/stafflist\/index.php?rest_route=\/wp\/v2\/posts\/55"}],"collection":[{"href":"https:\/\/www.hirokoku-u.ac.jp\/rehabilitation\/info\/stafflist\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hirokoku-u.ac.jp\/rehabilitation\/info\/stafflist\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hirokoku-u.ac.jp\/rehabilitation\/info\/stafflist\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hirokoku-u.ac.jp\/rehabilitation\/info\/stafflist\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=55"}],"version-history":[{"count":0,"href":"https:\/\/www.hirokoku-u.ac.jp\/rehabilitation\/info\/stafflist\/index.php?rest_route=\/wp\/v2\/posts\/55\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hirokoku-u.ac.jp\/rehabilitation\/info\/stafflist\/index.php?rest_route=\/wp\/v2\/media\/56"}],"wp:attachment":[{"href":"https:\/\/www.hirokoku-u.ac.jp\/rehabilitation\/info\/stafflist\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=55"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hirokoku-u.ac.jp\/rehabilitation\/info\/stafflist\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=55"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hirokoku-u.ac.jp\/rehabilitation\/info\/stafflist\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=55"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}