Hypoxia affects Slc7a5 expression through HIF-2α in differentiated neuronal cells.
Onishi Y, Hiraiwa M, Kamada H, Iezaki T, Yamada T, Kaneda K, Hinoi E
FEBS open bio 9(2) 241-247 Feb 2019

The MAPK Erk5 is necessary for proper skeletogenesis involving a Smurf-Smad-Sox9 molecular axis.
Iezaki T, Fukasawa K, Horie T, Park G, Robinson S, Nakaya M, Fujita H, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Yoneda Y, Takarada T, Guo XE, Kurose H, Hinoi E
Development (Cambridge, England) 145(14) Jul 2018

Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis.
Iezaki T, Horie T, Fukasawa K, Kitabatake M, Nakamura Y, Park G, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Manabe T, Ishigaki Y, Ohno M, Hinoi E
Stem cell reports 11(1) 228-241 Jul 2018

Hypoxic Stress Upregulates the Expression of Slc38a1 in Brown Adipocytes via Hypoxia-Inducible Factor-1α.
Horie T, Fukasawa K, Iezaki T, Park G, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Hinoi E
Pharmacology 101(1-2) 64-71  2018

Daily oral intake of β-cryptoxanthin ameliorates neuropathic pain.
Park G, Horie T, Iezaki T, Okamoto M, Fukasawa K, Kanayama T, Ozaki K, Onishi Y, Sugiura M, Hinoi E
Bioscience, biotechnology, and biochemistry 81(5) 1014-1017 May 2017

The transcriptional modulator Ifrd1 controls PGC-1α expression under short-term adrenergic stimulation in brown adipocytes.
Park G, Horie T, Kanayama T, Fukasawa K, Iezaki T, Onishi Y, Ozaki K, Nakamura Y, Yoneda Y, Takarada T, Hinoi E
The FEBS journal 284(5) 784-795 Mar 2017

The transcriptional modulator Ifrd1 is a negative regulator of BMP-2-dependent osteoblastogenesis.
Onishi Y, Park G, Iezaki T, Horie T, Kanayama T, Fukasawa K, Ozaki K, Hinoi E
Biochemical and biophysical research communications 482(2) 329-334 Jan 2017

Amelioration of the Development of Osteoarthritis by Daily Intake of β-Cryptoxanthin.
Park G, Horie T, Fukasawa K, Ozaki K, Onishi Y, Kanayama T, Iezaki T, Kaneda K, Sugiura M, Hinoi E
Biological & pharmaceutical bulletin 40(7) 1116-1120  2017

Transcriptional Modulator Ifrd1 Regulates Osteoclast Differentiation through Enhancing the NF-κB/NFATc1 Pathway.
Iezaki T, Fukasawa K, Park G, Horie T, Kanayama T, Ozaki K, Onishi Y, Takahata Y, Nakamura Y, Takarada T, Yoneda Y, Nakamura T, Vacher J, Hinoi E
Molecular and cellular biology 36(19) 2451-2463 Oct 2016

ATF3 deficiency in chondrocytes alleviates osteoarthritis development.
Iezaki T, Ozaki K, Fukasawa K, Inoue M, Kitajima S, Muneta T, Takeda S, Fujita H, Onishi Y, Horie T, Yoneda Y, Takarada T, Hinoi E
The Journal of pathology 239(4) 426-437 Aug 2016

ATF3 controls proliferation of osteoclast precursor and bone remodeling.
Fukasawa K, Park G, Iezaki T, Horie T, Kanayama T, Ozaki K, Onishi Y, Takahata Y, Yoneda Y, Takarada T, Kitajima S, Vacher J, Hinoi E
Scientific reports 6 30918 Aug 2016

The Transcriptional Modulator Interferon-Related Developmental Regulator 1 in Osteoblasts Suppresses Bone Formation and Promotes Bone Resorption.
Iezaki T, Onishi Y, Ozaki K, Fukasawa K, Takahata Y, Nakamura Y, Fujikawa K, Takarada T, Yoneda Y, Yamashita Y, Shioi G, Hinoi E
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 31(3) 573-584 Mar 2016

GDF1 is a novel mediator of macrophage infiltration in brown adipose tissue of obese mice.
Onishi Y, Fukasawa K, Ozaki K, Iezaki T, Yoneda Y, Hinoi E
Biochemistry and biophysics reports 5 216-223 Mar 2016

Overexpression of BCLXL in Osteoblasts Inhibits Osteoblast Apoptosis and Increases Bone Volume and Strength.
Moriishi T, Fukuyama R, Miyazaki T, Furuichi T, Ito M, Komori T.
J Bone Miner Res. 2016 Feb 8. doi: 10.1002/jbmr.2808. [Epub ahead of print]

Daily intake of β-cryptoxanthin prevents bone loss by preferential disturbance of osteoclastic activation in ovariectomized mice.
Ozaki K, Okamoto M, Fukasawa K, Iezaki T, Onishi Y, Yoneda Y, Sugiura M, Hinoi E
Journal of pharmacological sciences 129(1) 72-77 Sep 2015

Dephosphorylation of endogenous GABA(B) receptor R2 subunit and AMPK α subunits which were measured by in vitro method using transfer membrane.
Kuramoto N, Ito M, Saito Y, Niihara H, Tanaka N, Yamada K, Yamamura Y, Iwasaki K, Onishi Y, Ogita K
Neurochemistry international 62(2) 137-144 Jan 2013

Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis.
Wang Y, Liu W, Masuyama R, Fukuyama R, Ito M, Zhang Q, Komori H, Murakami T, Moriishi T, Miyazaki T, Kitazawa R, Yoshida CA, Kawai Y, Izumi S, Komori T.
Bone. 2012 Jan;50(1):409-19.

SP7 inhibits osteoblast differentiation at a late stage in mice.
Yoshida CA, Komori H, Maruyama Z, Miyazaki T, Kawasaki K, Furuichi T, Fukuyama R, Mori M, Yamana K, Nakamura K, Liu W, Toyosawa S, Moriishi T, Kawaguchi H, Takada K, Komori T.
PLoS One. 2012;7(3):e32364. doi: 10.1371/journal.pone.0032364. Epub 2012 Mar 2.

Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading.
Moriishi T, Fukuyama R, Ito M, Miyazaki T, Maeno T, Kawai Y, Komori H, Komori T.
PLoS One. 2012;7(6):e40143. doi: 10.1371/journal.pone.0040143. Epub 2012 Jun 29.

Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis.
Moriishi T, Maruyama Z, Fukuyama R, Ito M, Miyazaki T, Kitaura H, Ohnishi H, Furuichi T, Kawai Y, Masuyama R, Komori H, Takada K, Kawaguchi H, Komori T.
PLoS One. 2011;6(11):e27487. doi: 10.1371/journal.pone.0027487. Epub 2011 Nov 17.

Antihypertensive effects of continuous oral administration of nattokinase and its fragments in spontaneously hypertensive rats.
Fujita M, Ohnishi K, Takaoka S, Ogasawara K, Fukuyama R, Nakamuta H.
Biol Pharm Bull. 2011;34(11):1696-701.

Anti-osteoporosis effect of 5-bromo-2-(4-chlorobenzoyl)-(Z)-3-(2-cyano-3-hydroxybut-2-enonyl)aminobenzo[b]furan: a novel selective estrogen receptor modulator.
Fukuyama R, Shimokawa A, Kodama Y, Fujita M, Ohishi Y, Ando Y, Koida M, Nakamuta H.
J Pharmacol Sci. 2011;116(2):214-20. Epub 2011 May 21.

Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency.
Maruyama Z, Yoshida CA, Furuichi T, Amizuka N, Ito M, Fukuyama R, Miyazaki T, Kitaura H, Nakamura K, Fujita T, Kanatani N, Moriishi T, Yamana K, Liu W, Kawaguchi H, Nakamura K, Komori T.
Dev Dyn. 2007 Jul;236(7):1876-90.

Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development.
Kanatani N, Fujita T, Fukuyama R, Liu W, Yoshida CA, Moriishi T, Yamana K, Miyazaki T, Toyosawa S, Komori T.
Dev Biol. 2006 Aug 1;296(1):48-61. Epub 2006 Apr 4.