薬学の世界

18 Labs

薬の効き方 薬効解析学研究室

学術論文

Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass.  
Takeshi Moriishi, Ryosuke Ozasa, Takuya Ishimoto, Takayoshi Nakano, Tomoka Hasegawa, Toshihiro Miyazaki, Wenguang Liu, Ryo Fukuyama, Yuyin Wang, Hisato Komori, Xin Qin, Norio Amizuka, Toshihisa Komori 
PLOS Genet.in press 2020

Hypoxia affects Slc7a5 expression through HIF-2α in differentiated neuronal cells.
Onishi Y, Hiraiwa M, Kamada H, Iezaki T, Yamada T, Kaneda K, Hinoi E
FEBS open bio 9(2) 241-247 Feb 2019

The transcriptional modulator Ifrd1 is a negative regulator of BMP-2-dependent osteoblastogenesis.
Onishi Y, Park G, Iezaki T, Horie T, Kanayama T, Fukasawa K, Ozaki K, Hinoi E
Biochemical and biophysical research communications 482(2) 329-334 Jan 2017

GDF1 is a novel mediator of macrophage infiltration in brown adipose tissue of obese mice.
Onishi Y, Fukasawa K, Ozaki K, Iezaki T, Yoneda Y, Hinoi E
Biochemistry and biophysics reports 5 216-223 Mar 2016

Overexpression of BCLXL in Osteoblasts Inhibits Osteoblast Apoptosis and Increases Bone Volume and Strength.
Moriishi T, Fukuyama R, Miyazaki T, Furuichi T, Ito M, Komori T.
J Bone Miner Res. 2016 Feb 8. doi: 10.1002/jbmr.2808. [Epub ahead of print]

Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis.
Wang Y, Liu W, Masuyama R, Fukuyama R, Ito M, Zhang Q, Komori H, Murakami T, Moriishi T, Miyazaki T, Kitazawa R, Yoshida CA, Kawai Y, Izumi S, Komori T.
Bone. 2012 Jan;50(1):409-19.

SP7 inhibits osteoblast differentiation at a late stage in mice.
Yoshida CA, Komori H, Maruyama Z, Miyazaki T, Kawasaki K, Furuichi T, Fukuyama R, Mori M, Yamana K, Nakamura K, Liu W, Toyosawa S, Moriishi T, Kawaguchi H, Takada K, Komori T.
PLoS One. 2012;7(3):e32364. doi: 10.1371/journal.pone.0032364. Epub 2012 Mar 2.

Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading.
Moriishi T, Fukuyama R, Ito M, Miyazaki T, Maeno T, Kawai Y, Komori H, Komori T.
PLoS One. 2012;7(6):e40143. doi: 10.1371/journal.pone.0040143. Epub 2012 Jun 29.

Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis.
Moriishi T, Maruyama Z, Fukuyama R, Ito M, Miyazaki T, Kitaura H, Ohnishi H, Furuichi T, Kawai Y, Masuyama R, Komori H, Takada K, Kawaguchi H, Komori T.
PLoS One. 2011;6(11):e27487. doi: 10.1371/journal.pone.0027487. Epub 2011 Nov 17.

Antihypertensive effects of continuous oral administration of nattokinase and its fragments in spontaneously hypertensive rats.
Fujita M, Ohnishi K, Takaoka S, Ogasawara K, Fukuyama R, Nakamuta H.
Biol Pharm Bull. 2011;34(11):1696-701.

Anti-osteoporosis effect of 5-bromo-2-(4-chlorobenzoyl)-(Z)-3-(2-cyano-3-hydroxybut-2-enonyl)aminobenzo[b]furan: a novel selective estrogen receptor modulator.
Fukuyama R, Shimokawa A, Kodama Y, Fujita M, Ohishi Y, Ando Y, Koida M, Nakamuta H.
J Pharmacol Sci. 2011;116(2):214-20. Epub 2011 May 21.

Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency.
Maruyama Z, Yoshida CA, Furuichi T, Amizuka N, Ito M, Fukuyama R, Miyazaki T, Kitaura H, Nakamura K, Fujita T, Kanatani N, Moriishi T, Yamana K, Liu W, Kawaguchi H, Nakamura K, Komori T.
Dev Dyn. 2007 Jul;236(7):1876-90.

Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development.
Kanatani N, Fujita T, Fukuyama R, Liu W, Yoshida CA, Moriishi T, Yamana K, Miyazaki T, Toyosawa S, Komori T.
Dev Biol. 2006 Aug 1;296(1):48-61. Epub 2006 Apr 4.

学会発表

八味地黄丸は酸化ストレスによる培養軟骨細胞の軟骨基質産生抑制を阻害する
大西 勇気、大判 恵里、菊池 晴香、田中 萌恵、真弓 智行、福山 亮金子 哲夫、中島 正光、藤田 貢
第37回和漢医薬学会学術大会 2020年8月

八味地黄丸は骨芽細胞への分化、骨形成を促進し、破骨細胞への分化、骨吸収活性を抑制する
山口 萌、野村 悠、大西 勇気、福山 亮、中島 正光、藤田 貢
日本薬学会第140年会 2020年3月

独活寄生丸は骨芽細胞への分化、骨形成を促進し、破骨細胞への分化、骨吸収活性を抑制する
木谷 光志、島岡 昇哉、大西 勇気、福山 亮、中島 正光、藤田 貢
日本薬学会第140年会 2020年3月

漢方薬の骨形成・骨吸収に対する影響 ~in vitroでの検討~
大西 勇気, 藤田 貢, 中島 正光, 福山 亮
アカデミア発シーズ探索研究会2019(予防薬理学研究所)  2019年9月

 

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