Molecular epidemiological and pharmaceutical studies of methicillin-resistant Staphylococcus aureus isolated at hospitals in Kure City, Japan Open Access Maeda R, Kobayashi H, Higashidani M, Matsuhisa T, Sawa A, Miyake K, Tayama Y, Kimura K, Itoh H, Okano T, Seike S, Yamanaka H (2022) Access Microbiol. 25:000319. (https://www.microbiologyresearch.org/content/journal/acmi/10.1099/acmi.0.000319)
Aeromonas sobria Serine Protease Degrades Several Protein Components of Tight Junctions and Assists Bacterial Translocation Across the T84 Monolayer Ueda M, Kobayashi H, Seike S, Takahashi E, Okamoto K and Yamanaka H (2022) Front. Cell. Infect. Microbiol. 22:824547. (https://www.frontiersin.org/articles/10.3389/fcimb.2022.824547/full) Outer membrane vesicles released from Aeromonas strains are involved in the biofilm formation Seike S, Kobayashi H, Ueda M, Takahashi E, Okamoto K, Yamanaka H (2021) Front. Microbiol. 11:613650. (https://www.frontiersin.org/articles/10.3389/fmicb.2020.613650/full)
Aeromonas sobria serine protease decreases epithelial barrier function in T84 cells and accelerates bacterial translocation across the T84 monolayer in vitro Kobayashi H, Seike S, Yamaguchi M, Ueda M, Takahashi E, Okamoto K, Yamanaka H (2019) PLOS ONE 16;14(8):e0221344. (https://doi.org/10.1371/journal.pone.0221344) ABO blood group A transferase and its codon 69 substitution enzymes synthesize FORS1 antigen of FORS blood group system Miyako Yamamoto, Maria Cristina Tarasco, Emili Cid, Hidetomo Kobayashi, and Fumiichiro Yamamoto, Scientific Reports, volume 9, Article number: 9717 (2019) (https://www.nature.com/articles/s41598-019-46029-7) Aeromonas sobria serine protease decreases epithelial barrier function in T84 cells and accelerates bacterial translocation across the T84 monolayer in vitro Hidetomo Kobayashi, Soshi Seike, Masafumi Yamaguchi, Mitsunobu Ueda, Eizo Takahashi, Keinosuke Okamoto, Hiroyasu Yamanaka PLOS ONE 16: e0221344.(2019) (https://www.hirokoku-u.ac.jp/pharm/m_microbiological/the_action_of_asp_on_the_intestinal_tissue/)
Involvement of the Arg566 residue of Aeromonas sobria serine protease in substrate specificity
Hidetomo Kobayashi, Tadamune Otsubo, Fumiteru Teraoka, Kiyoshi Ikeda, Soshi Seike, Eizo Takahashi, Keinosuke Okamoto, Toru Yoshida, Hideaki Tsuge, Hiroyasu Yamanaka
PLoS ONE 12: e0186392.(2017) （https://www.hirokoku-u.ac.jp/pharm/m_microbiological/the-substrate-specificity-of-asp/）
Structural Basis for Action of the External Chaperone for a Propeptide-deficient Serine Protease from Aeromonas sobria
Hidetomo Kobayashi, Toru Yoshida, Takuya Miyakawa, Mitsuru Tashiro, Keinosuke Okamoto, Hiroyasu Yamanaka, Masaru Tanokura and Hideaki Tsuge
J. Biol. Chem. 290: 11130-11143 (2015) （ニュース・トピックスhttp://www.hirokoku-u.ac.jp/information/2015/17495/17489.html）
Properties of hemolysin and protease produced by Aeromonas trota
Eizo Takahashi, Haruka Ozaki, Yoshio Fujii, Hidetomo Kobayashi, Hiroyasu Yamanaka, Sakae Arimoto, Tomoe Negishi and Keinosuke Okamoto
PLoS One 9: e91149 (2014)
Analysis of Carboxy Terminal Domain of Metalloprotease of Elastolytic Aeromonas hydrophila
Eizo Takahashi, Hidetomo Kobayashi, Hiroyasu Yamanaka, Mayu Nakanishi, Arisa Tateishi, Takemi Abe, Sakae Arimoto, Tomoe Negishi and Keinosuke Okamoto
Biol. Pharm. Bull. 36:1174-1182 (2013)
The tail nick augments Aeromonas sobria serine protease (ASP) activity in plasma through retarding inhibition by a2-macroglobulin
Yoji Murakami, Yoshihiro Wada, Hidetomo Kobayashi, Makoto Hasegawa, Keinosuke Okamoto, Masatoshi Eto and Takahisa Imamura
FEBS Lett. 586: 3613-3617 (2012)
Inhibition of Aeromonas sobria serine protease (ASP) by α2-macroglobulin
Yoji Murakami, Yoshihiro Wada, Hidetomo Kobayashi, Atsushi Irie, Makoto Hasegawa, Hiroyasu Yamanaka, Keinosuke Okamoto, Masatoshi Eto and Takahisa Imamura
Biol. Chem. 393: 1193–1200 (2012)
Production and properties of lipase of Aeromonas sobria
Eizo Takahashi, Hidetomo Kobayashi, Hiroyasu Yamanaka, Yoshifumi Takeda, Gopinath Balakrish Nair, Sakae Arimoto, Tomoe Negishi and Keinosuke Okamoto
Microbiol. Immunol. 5: 295-307 (2012)
Structural and functional analysis of the serine protease from Aeromonas sobria
Hidetomo Kobayashi
YAKUGAKU ZASSHI 12: 1781-1786 (2011)
Inhibition of biosynthesis of metalloprotease of Aeromonas sobria by sodium chloride in the medium
Eizo Takahashi, Hidetomo Kobayashi, Hiroyasu Yamanaka, Gopinath Balakrish Nair, Yoshifumi Takeda, Sakae Arimoto, Tomoe Negishi and Keinosuke Okamoto
Microbiol. Immunol. 1: 60-5 (2011)
Maturation pathway of metalloprotease produced by Aeromonas sobria
Eizo Takahashi, Yoshio Fujii, Hidetomo Kobayashi, Hiroyasu Yamanaka, Gopinath Balakrish Nair, Yoshifumi Takeda, Sakae Arimoto, Tomoe Negishi and Keinosuke Okamoto
Microbiol. Immunol. 54: 596-605 (2010)
The carboxy-terminal tail of Aeromonas sobria serine protease is associated with the chaperone
Hidetomo Kobayashi, Arisa Tateishi , Hideaki Tsuge, Eizo Takahashi, Keinosuke Okamoto and Hiroyasu Yamanaka
Microbiol. Immunol. 53: 647-57 (2009)
Structural basis for the kexin-like serine protease from Aeromonas sobria as a sepsis-causing factor
Hidetomo Kobayashi, Hiroko Utsunomiya, Hiroyasu Yamanaka, Yoshihisa Sei, Nobuhiko Katunuma, Keinosuke Okamoto and Hideaki Tsuge
J. Biol. Chem. 284: 27655-27663 (2009)
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II
Hiroyasu Yamanaka, Hidetomo Kobayashi, Eizo Takahashi and Keinosuke Okamoto.
J. Bacteriol. 190: 7693-7698 (2008)
Production of C5a by ASP, a serine protease released from Aeromonas sobria
Hidetoshi Nitta, Takahisa Imamura, Yoshihiro Wada, Atsushi Irie, Hidetomo Kobayashi, Keinosuke Okamoto and Hideo Baba.
J. Immunol. 181: 3602-3608 (2008)
Impaired plasma clottability induction through fibrinogen degradation by ASP, a serine protease released from Aeromonas sobria
Takahisa Imamura, Hidetoshi Nitta, Yoshihiro Wada, Hidetomo Kobayashi and Keinosuke Okamoto.
FEMS Microbiol. Lett. 284: 35-42 (2008)
Design and synthesis of benzenesulfonanilides active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus
Kensuke Namba, Xiaoxia Zheng, Kazunori Motoshima, Hidetomo Kobayashi, Akihiro Tai, Eizo Takahashi, Kenji Sasaki, Keinosuke Okamoto, Hiroki Kakuta
Bioorg Med Chem. 1: 6131-44 (2008)
Activation of prothrombin by ASP, a serine protease released from Aeromonas sobria
Hidetoshi Nitta, Hidetomo Kobayashi, Atsushi Irie, Hideo Baba, Keinosuke Okamoto and Takahisa Imamura.
FEBS Lett. 581: 5935-5939 (2007)
Studied on the region involved in the transport activity of Escherichia coli TolC by chimeric protein analysis
Hiroyasu Yamanaka, Satoshi Tadokoro, Masaya Miyano, Eizo Takahashi, Hidetomo Kobayashi and Keinosuke Okamoto.
Microb. Pathog. 42: 184-192 (2007)
Induction of vascular leakage and blood pressure lowering through kinin release by a serine proteinase from Aeromonas sobria
Takahisa Imamura, Hidetomo Kobayashi, Rasel Khan and Keinosuke Okamoto.
J. Immunol. 117: 8723-8729 (2006)
Cleavage specificity of the serine protease of Aeromonas sobria, a member of the kexin family of subtilases
Hidetomo Kobayashi, Eizo Takahashi, Keiji Oguma, Yoshio Fujii, Hiroyasu Yamanaka, Tomoe Negishi, Sakae Arimoto-Kobayashi, Takao Tsuji and Keinosuke Okamoto.
FEMS Microbiol. Lett. 256: 165-170 (2006)
